摘要
Abstract
Objective To explore the clinical and pathologic features of the mucinous tubular and spindle cell carcinoma (MTSCC) of kidney. Methods The clinical features, tissue morphology and immunophenotypes (including CD10, CK7, EMA, P5O4S and Vimentin) of 3 cases of MTSCC were analyzed, and the related literature was reviewed. Results Among the 3 MTSCC patients, 1 was male and 2 were females, aged from 39 to 57 years with a mean age of 48. The diameter of tumors ranged from 4. 2cm to 9. Ocm with a mean of 5. 9cm. The 3 patients were followed-up for 18 to 44 months, and no recurrence or metastasis was found. Under general observation, the tumor was well-circumscribed, without capsule, and the cut surface was solid and grayish-white. Light microscopy showed that the tumor was composed of tightly packed, small, elongated tubules with transition to spindle cell components, while in 1 case it lacked spindle cell area; mucinous stroma was seen in 2 cases, and clear cells, papillary structures and foam cells were seen in 1 case. Immunohistochemical staining showed that CK7, EMA and P504S were positive in 3 cases, CD10 was positive in 1 case and Vimentin was weakly positive in 2 cases. Conclusions MTSCC is a low-grade and polymorphic tumor with a wide histological spectrum, consisting of tubules and spindle cells (may lack one of them, or lack of mucinous stroma), coupled with clear cells and papillary structures in some cases, and expresses the markers of proximal and distal nephron.关键词
癌，肾细胞/黏液性管状和梭形细胞癌/病理学Key words
carcinoma, renal cell/ mucinous tubular and spindle cell carcinoma/ pathology分类
医药卫生
