肿瘤预防与治疗2011，Vol.24Issue(6)：284-289,6.DOI:10.3969/j.issn.1674-0904.2011.06.001
卵巢上皮癌铂类耐药与非耐药细胞间核苷酸切除修复基因多态性的检测
Analysis of Genetic Polymorphisms in Nucleotide Excision Repair System in Platinum Drug Resistant and Non-resistant Ovarian Cancer Cells
摘要
Abstract
O bjective: To examine the correlations of polymorphisns ofERCQ ^XPA^XPC, XPT\ XPG in nucleotide excision repair systan and the sensitivity of plathum-based chenotherapy in epithelial ovarian cancer M e1hods: PCR and sequencing were perfomed to screen the single nucleotide polymorphisms of exons ofERCQ ^ XPA, XPC, XPI\ XPG in epithelial ovarian cancer cells which were resistant or sensitive to platinum-based treatnent The results were analyzed by Chranas software andNCBENP data bank to search and authenticate the SNPs Results; XPGH i46His and XPG H I§ 104 Asp had polymorphisms in cells Conclusion: The polymorphisms ofXPGHi46H is and XPG HH104 Asp innucleotHe excision repair systanmay be associated with the resistance of epithelial ovarian cancer after platinum-based chemotherapy关键词
卵巢癌/基因遗传多态/XPG/药物敏感性Key words
Ovarian Cancer Genetic Polymorphism XPG/ Drug Sensitivity分类
医药卫生引用本文复制引用
张玮,吴飞翔,王琪,黎丹戒,李力..卵巢上皮癌铂类耐药与非耐药细胞间核苷酸切除修复基因多态性的检测[J].肿瘤预防与治疗,2011,24(6):284-289,6.基金项目
广西自然科学基金(桂科自0832129) （桂科自0832129）
