山西医科大学学报2011，Vol.42Issue(11)：864-868,938,6.DOI:10.3969/J.ISSN.1007-6611.2011.11.002
长时间应用大剂量的左旋精氨酸对幼鼠学习记忆功能和神经系统可塑性的抑制作用
Long-lasting administration of large dose of L-arginine suppresses the learning and memory and the plasticity of nervous system in junior rats
摘要
Abstract
Objective To study the effects of long-lasting administration of large dose of L-arginine(L-Arg) on the ability of learning and memory and the plasticity of nervous system in junior rats. Methods The weanling rats were commensurate distilled water (control group,n=10) for three months,respectively.The ability of learning and memory was observed by Morris water maze.Then nNOS (neuronal NOS) or c-fos expression with immunocytochemisity and the number of neuronal cells with HE staining in cerebral cortex and CA1,CA3,DG of hippocampus were detected. Results The latency to find the platform and the expression of nNOS were significantly higher in L-Arg group than that in control group,but the expression of c-fos and the number of neuronal cells in cerebral cortex and CA1,CA3,DG of hippocampus were markedly lower in L-Arg group than that in control group (P<0.05 or P<0.01). Conclusion The results suggest that long-lasting use of L-Arg with large dose can inhibit the ability of learning and memory and the plasticity of nervous system in the developing brain.关键词
左旋精氨酸/nNOS/c-fos/学习记忆/可塑性/大脑皮质/海马Key words
L-arginine/neuronal nitric oxide synthase/c-fos/learning and memory/plasticity/cerebral cortex/hippocampus分类
生物科学引用本文复制引用
淮盼盼,赵建强,王奕,叶敏,青莎,刘丽霞,高胜利,赵成瑞,祁文秀..长时间应用大剂量的左旋精氨酸对幼鼠学习记忆功能和神经系统可塑性的抑制作用[J].山西医科大学学报,2011,42(11):864-868,938,6.基金项目
山西省大学生创新实验基金资助项目(2009103) （2009103）
山西省高校科技研究开发基金资助项目(200354)demonstrate the （200354）
