中国全科医学2011，Vol.14Issue(31)：3585-3587,3.
早期肠内营养联合质子泵抑制剂对脑卒中应激性溃疡的防治作用研究
Early Enteral Nutrition with Proton Pump Inhibitor for Prevention and Control of Stress Ulceration in Patients with Acute Stroke
摘要
Abstract
Objective To investigate the effect of early enteral nutrition combined with proton pump inhibitor ( PPI ) to prevent and control the stress ulceration in patients with acute stroke. Methods Sixty - six patients with acute stroke were randomly allocated into two groups, or group A ( early enteral nutrition and intravenous injection of Omeprazole 40 mg twice a day ) and group B ( intravenous injection of Omeprazole 40 mg twice a day ), with 33 in each. Intragastric pH over 24 hours was recorded on the sixth day for each patient. The incidence of stress ulceration was observed, and the clinical effects were evaluated two weeks later. Results The mean intragastric pH and median intragastric pH over 24 hours, nocturnal mean pH and median pH, and the fraction time of mean intragastric pH below 4. 0 for the whole day and at night in group A were significantly different with those in group B ( P < 0. 05 ) . The morbidity rate of stress ulceration in group A was lower than that in group B ( P < 0. 05 ) . And the rates of cure and improvement in group A were higher than those in group B ( P < 0. 05 ) . Conclusion The early enteral nutrition combined with PPI has a certain preventive and controlling effects for development of stress ulceration, and the possible mechanism may be adjusting the intragastric pH.关键词
脑卒中/应激性溃疡/肠内营养/质子泵抑制剂Key words
Stroke/ Stress ulcer/ Enteral nutrition/ Proton pump inhibitor分类
医药卫生引用本文复制引用
赵宏军,张晓苹,王黎萍,吴承龙,马阿火..早期肠内营养联合质子泵抑制剂对脑卒中应激性溃疡的防治作用研究[J].中国全科医学,2011,14(31):3585-3587,3.基金项目
绍兴市重点科技计划项目(2008A23002) （2008A23002）
