中国全科医学2011，Vol.14Issue(33)：3814-3817,4.
汉族可溶性环氧化物酶基因多态性与颅内动脉瘤的关系研究
Relationship between Soluble Epoxide Hydrolase Gene Polymorphism and Intracranial Aneurysm in the Han Nationality
邱虹 1刘志忠 2杨军 2康熙雄 1阚志生2
作者信息
- 1. 063000,河北省唐山市,开滦集团有限责任公司医院神经外科
- 2. 首都医科大学附属北京天坛医院实验诊断中心
- 折叠
摘要
Abstract
Objective To explore the relationship between the polymorphism of the soluble epoxide hydrolase ( EPHX2 ) gene and the incidence of intracranial aneurysm in the Han nationality. Methods Two hundred and thirty eight patients with intracranial aneurysms and 221 controls were studied, the genotype and allelic frequency of the EPHX2 rs751141 and rs2291635 polymorphism were analyzed by polymerase chain reaction ( PCR ) and sequencing of the PCR products. Results EPHX2 rs751141 polymorphism was significantly different between the aneurysm group [ with a ( GA + AA ) genotype of 22. 2% ] and the control group [ with a ( GA + AA ) genotype of 41. 7% ] among females ( P =0. 002 ) . However, this association wasn' t found in males and in all subjects regardless of genders ( P > 0. 05 ) . No significant difference was seen in the genotype and allelic frequency of rs2291635 polymorphism between patients and controls in male, female or all subjects. Conclusion The rs751141 polymorphism of EPHX2 is correlated with the pathogenesis of intracranial aneurysms in the Han nationality.关键词
可溶性环氧化物酶基因/聚合酶链反应/多态性,单核苷酸/颅内动脉瘤Key words
EPHX2 gene/ Polymerase chain reaction/ Polymorphism, single nucleotide/ Intracranial aneurysm分类
医药卫生引用本文复制引用
邱虹,刘志忠,杨军,康熙雄,阚志生..汉族可溶性环氧化物酶基因多态性与颅内动脉瘤的关系研究[J].中国全科医学,2011,14(33):3814-3817,4.
