山东医药2011，Vol.51Issue(28)：26-28,3.
普罗布考对高脂血症大鼠内皮功能的影响
Effects of probucol on the endothelial function of hyperlipidemia rats
摘要
Abstract
Objective To study the effects of probucol on the endothelial function of hyperlipidemia rats. Methods Fifty SD rats were randomly divided into S groups; the control group (group A) , high fat diet group (group B) , high fat diet + VitD3 (ip) group (group C), high fat diet + probucol group (group D) , high fat diet + VitD3 (ip) + probucol group (group E). At the 16th week, the hemodynamic study was performed, then blood samples were collected for the tests of TG, TC, HDL-C, LDL-C, NO, NOS, T-AOC, MDA activity. Then arteriae aortas were collected for HE staining. Results In high fat diet groups, the plasma levels of TG, TC, LDL-C, NO, NOS elevated (P<0.01); HDL-C level decreased (P < 0.01). In probucol intervened rats, the plasma levels of NO, NOS, T-AOC elevated (P < 0.05), while TC, HDL-C, LDL-C, MDA levels decreased (P < 0.05 ). At the end of study, the extent of blood pressure decreasing after infusing sodium nitroprusside was significantly higher than acetylcholine in group C ( P < 0. 05 ). Conclusion Probucol can improve endothelium-dependent vascular relaxation dysfunction.关键词
普罗布考/高脂血症/动脉硬化/氧化性应激/内皮功能障碍Key words
probucol/ hyperlipidemia/ atherosclerosis/ oxidative stress/ endothelium dysfunction分类
医药卫生引用本文复制引用
赵凯,杨万松,党群,李永健,刘洪梅,黄体钢..普罗布考对高脂血症大鼠内皮功能的影响[J].山东医药,2011,51(28):26-28,3.基金项目
天津市卫生局科技基金资助项目(06KZ36)；天津市科学技术成果(津20085592). （06KZ36）
