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Effects of MCI-186 on intracellular calcium ion concentration and membrane fluidity of hippocampal neurons in a rat model of Alzheimer's disease

Ming Yu Lei Qin Zhao Wang Xiaohong Lu Ying Zhu Wenhui Leng Xuan Wang

中国神经再生研究（英文版）2011，Vol.6Issue(29)：2245-2250,6.

中国神经再生研究（英文版）2011，Vol.6Issue(29)：2245-2250,6.DOI:10.3969/j.issn.1673-5374.2011.29.001

Effects of MCI-186 on intracellular calcium ion concentration and membrane fluidity of hippocampal neurons in a rat model of Alzheimer's disease

Ming Yu ¹Lei Qin ²Zhao Wang ³Xiaohong Lu ⁴Ying Zhu ¹Wenhui Leng ¹Xuan Wang⁴

作者信息

1. Department of Neurology, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, Jiangsu Province, China
2. Department of Preventive Medicine, Nanjing University of Chinese Medicine, Nanjing 210046, Jiangsu Province, China
3. Department of Biochemistry, Basic Medical College of Jiamusi University, Jiamusi 154007, Heilongjiang Province, China
4. Department of Neurology, Affiliated First Hospital of Jiamusi University, Jiamusi 154002, Heilongjiang Province, China
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摘要

Abstract

The present study observed the effects of MCI-186 on the intracellular calcium ion concentration ([Ca2+]i) and membrane fluidity of hippocampal neurons in Alzheimer's disease (AD) model rats to validate the neuroprotective effects of MCI-186. Compared with normal and sham-operated rats, the escape latency was obviously prolonged, spanning platform times were obviously reduced, [Ca2+]i was increased, and microviscosity η value was increased in AD rats. MCI-186 at 0.5 mg/mL and 0.2 mg/mL obviously shortened escape latency, increased spanning platform times and decreased [Ca2+]i and microviscosity η values in AD rats at 7 and 17 days after induction of the model. The differences in the above-mentioned indices between normal and MCI-186-treated rats were statistically significant. MCI-186 at 0.2 mg/mL yielded better curative effects than 0.5 mg/mL MCI-186. These findings suggest that MCI-186 improves learning and memory abilities in AD rats by decreasing [Ca2+]i and increasing membrane fluidity of hippocampal neurons.

关键词

MCI-186/Alzheimer's disease/learning/memory/calcium ion/neurodegenerative diseases/neural regeneration

Key words

MCI-186/Alzheimer's disease/learning/memory/calcium ion/neurodegenerative diseases/neural regeneration

引用本文复制引用

Ming Yu,Lei Qin,Zhao Wang,Xiaohong Lu,Ying Zhu,Wenhui Leng,Xuan Wang..Effects of MCI-186 on intracellular calcium ion concentration and membrane fluidity of hippocampal neurons in a rat model of Alzheimer's disease[J].中国神经再生研究（英文版）,2011,6(29):2245-2250,6.

基金项目

the Natural Science Foundation of Heilongjiang Province,No.D200807 （）

Projects of Clinical Medicine in Science and Technology Development of Jiangsu University,No.JLY20080013 （）

中国神经再生研究（英文版）

OACSCDSCI

ISSN：1673-5374

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