中国神经再生研究（英文版）2011，Vol.6Issue(29)：2251-2255,5.DOI:10.3969/j.issn.1673-5374.2011.29.002
Telencephalin protects Paju cells from beta-amyloid protein-induced apoptosis
Telencephalin protects Paju cells from beta-amyloid protein-induced apoptosis
Heping Yang 1Dapeng Wu 2Xiaojie Zhang 3Xiang Wang 2Yi Peng 4Zhiping Hu2
作者信息
- 1. Department of Neurology, Shangrao No.5 People's Hospital, the Second Affiliated Hospital of Branch to Nanchang University, Shangrao 334000, Jiangxi Province, China
- 2. Department of Neurology, Xiangya Second Hospital, Central South University, Changsha 410011, Hunan Province, China
- 3. Department of Neurology, Ruikang Hospital Affiliated to Guangxi Traditional Chinese Medical University, Nanning 530011, Guangxi Zhuang Autonomous Region, China
- 4. Department of Psychiatry, Xiangya Second Hospital, Central South University, Changsha 410011, Hunan Province, China
- 折叠
摘要
Abstract
Previous studies have confirmed that telencephalin (TLN) is a neural glycoprotein that protects axonal disruption induced by the beta-amyloid protein (Aβ42/35) in the neural crest-derived tumor cell line Paju. The present study investigated the effects of TLN on neuronal degeneration induced by Aβ42 in the differentiated Paju cell line. Results demonstrated that after cultivating cells in Aβ42 medium, the survival rate of Paju-TLN cells was significantly higher than that of Paju-neo cells, and that apoptotic rate was noticeably reduced. These results indicate that TLN reduces Paju cell apoptosis induced by Aβ42.关键词
telencephalin/intercellular adhesion molecule-5/beta-amyloid protein/neuroprotective effect/apoptosis/Alzheimer's disease/neural regenerationKey words
telencephalin/intercellular adhesion molecule-5/beta-amyloid protein/neuroprotective effect/apoptosis/Alzheimer's disease/neural regeneration引用本文复制引用
Heping Yang,Dapeng Wu,Xiaojie Zhang,Xiang Wang,Yi Peng,Zhiping Hu..Telencephalin protects Paju cells from beta-amyloid protein-induced apoptosis[J].中国神经再生研究（英文版）,2011,6(29):2251-2255,5.
