首页|期刊导航|中国神经再生研究（英文版）|Atorvastatin increases dynamin 1 expression in hippocampal CA1 region in a rat model of vascular dementia
中国神经再生研究（英文版）2011，Vol.6Issue(29)：2256-2261,6.DOI:10.3969/j.issn.1673-5374.2011.29.003
Atorvastatin increases dynamin 1 expression in hippocampal CA1 region in a rat model of vascular dementia
Atorvastatin increases dynamin 1 expression in hippocampal CA1 region in a rat model of vascular dementia
摘要
Abstract
The current study examined a rat model of vascular dementia. The model rats exhibited obvious morphological and ultrastructural changes in neurons in the brain, and significantly reduced dynamin 1 expression in hippocampal CA1 region along with decreased learning and memory performance. Following atorvastatin treatment, the morphology and ultrastructure of cells in the model rat brain were significantly improved, dynamin 1 expression in hippocampal CA1 region was significantly enhanced, and learning and memory ability was significantly improved. The results demonstrated that impaired learning and memory abilities in vascular dementia model rats were closely correlated with decreased dynamin 1 expression. These findings indicate that atorvastatin can protect model rats against cognitive impairment by increasing dynamin 1 expression.关键词
vascular dementia/Morris water maze test/ultrastructure/dynamin 1/atorvastatin/hippocampal CA1 region/neural regenerationKey words
vascular dementia/Morris water maze test/ultrastructure/dynamin 1/atorvastatin/hippocampal CA1 region/neural regeneration引用本文复制引用
Qinghua Li,Wensheng Zhou..Atorvastatin increases dynamin 1 expression in hippocampal CA1 region in a rat model of vascular dementia[J].中国神经再生研究（英文版）,2011,6(29):2256-2261,6.基金项目
the Science and Technology Development Program of Hunan Province,No.2008FJ3195 （）
