首页|期刊导航|中国神经再生研究（英文版）|Axonal damage in myelin oligodendrocyte glycoprotein peptide-induced experimental autoimmune encephalomyelitis in a C57BL/6 mouse model may be not secondary to inflammatory demyelination
中国神经再生研究（英文版）2011，Vol.6Issue(29)：2267-2272,6.DOI:10.3969/j.issn.1673-5374.2011.29.005
Axonal damage in myelin oligodendrocyte glycoprotein peptide-induced experimental autoimmune encephalomyelitis in a C57BL/6 mouse model may be not secondary to inflammatory demyelination
Axonal damage in myelin oligodendrocyte glycoprotein peptide-induced experimental autoimmune encephalomyelitis in a C57BL/6 mouse model may be not secondary to inflammatory demyelination
摘要
Abstract
The present study established a chronic experimental autoimmune encephalomyelitis model in C57BL/6 mice induced by myelin oligodendrocyte glycoprotein peptides and complete Freund's adjuvant. Onset latency was 12 days, with an incidence rate of 100%. Neuropathological characteristics included perivascular inflammatory cell infiltration, demyelination, neuronal degeneration, and axonal damage within cerebral and myelic white matter. Electron microscopy revealed swollen mitochondria, complete organ disappearance, and fused or broken myelin sheath structure, which were accompanied by myelin sheath reconstruction. Moreover, axonal damage was not consistent with demyelination distribution, and severity of axonal damage did not correlate with demyelination. Results suggested that axonal damage in an experimental autoimmune encephalomyelitis model is not secondary to inflammatory demyelination.关键词
axon/C57BL/6 mouse/experimental autoimmune encephalomyelitis/myelin oligodendrocyte glycoprotein/myelin sheath/neuropathology/neural regenerationKey words
axon/C57BL/6 mouse/experimental autoimmune encephalomyelitis/myelin oligodendrocyte glycoprotein/myelin sheath/neuropathology/neural regeneration引用本文复制引用
Boting Gao,Juan Chen,Qiong Wang,Wei Wang,Zhouping Tang..Axonal damage in myelin oligodendrocyte glycoprotein peptide-induced experimental autoimmune encephalomyelitis in a C57BL/6 mouse model may be not secondary to inflammatory demyelination[J].中国神经再生研究（英文版）,2011,6(29):2267-2272,6.基金项目
the Natural Science Foundation of Ministry of Science and Technology of China,No.30230140 （）
a grant from Merck Serono (China) （China）
