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Hepatic myelopathy Morphology of the thoracic and lumbar cord in liver cirrhosis and non-cirrhosis corpses and comparison of neuron functional protein

Yu Lei Zhen Liu Huilong Huang Suiliang Zhang Yunheng Zhou Shuai Wu Xiaojun Hou Jie Gong Aiqun Wu

中国神经再生研究（英文版）2011，Vol.6Issue(29)：2273-2278,6.

中国神经再生研究（英文版）2011，Vol.6Issue(29)：2273-2278,6.DOI:10.3969/j.issn.1673-5374.2011.29.006

Hepatic myelopathy Morphology of the thoracic and lumbar cord in liver cirrhosis and non-cirrhosis corpses and comparison of neuron functional protein

Yu Lei ¹Zhen Liu ²Huilong Huang ²Suiliang Zhang ³Yunheng Zhou ⁴Shuai Wu ⁵Xiaojun Hou ⁵Jie Gong ²Aiqun Wu²

作者信息

1. Department of Clinical Medicine, the Second Military Medical University of Chinese PLA, Shanghai 200433, China
2. Department of Anatomy, the Second Military Medical University of Chinese PLA, Shanghai 200433, China
3. Department of Interventional Therapy, Eastern Hepatobiliary Surgery Hospital, the Second Military Medical University of Chinese PLA, Shanghai 200433, China
4. Clinical Laboratory, Shanghai Armed Police Corps Hospital, Shanghai 201103, China
5. Department of Neurology, Changhai Hospital, the Second Military Medical University of Chinese PLA, Shanghai 200433, China
折叠

摘要

Abstract

The current study demonstrated that injury of the spinal cord lateral funiculus occurs in liver cirrhosis. This study sought to compare the morphology of the thoracic and lumbar cord, the expression of functional proteins, and changes in vessels between liver cirrhosis and non-cirrhosis corpses. Results showed that in the liver cirrhosis group, the hepatic vein expanded, the gastrointestinal tract was full of coagulated blood, blood-stasis was easily seen in the veniplex of the vertebral canal and the lumbar spinal cord, and the cell bodies of the anterior horn in the thoracic and lumbar cord were smaller than those in non-cirrhosis corpses. In addition, nerve cells shrank, Nissl bodies were concentrated with obscured nuclei, and neurofilament and synapsin containing cell bodies of the anterior horn and white matter decreased in the liver cirrhosis group. These experimental findings indicate that abnormal circulation of the spinal cord, resulting from hemodynamic change of cirrhotic portal hypertension, may be the most significant cause of hepatic myelopathy.

关键词

hepatic cirrhosis/portal hypertension/hepatic myelopathy/synapsin/neurofilament

Key words

hepatic cirrhosis/portal hypertension/hepatic myelopathy/synapsin/neurofilament

引用本文复制引用

Yu Lei,Zhen Liu,Huilong Huang,Suiliang Zhang,Yunheng Zhou,Shuai Wu,Xiaojun Hou,Jie Gong,Aiqun Wu..Hepatic myelopathy Morphology of the thoracic and lumbar cord in liver cirrhosis and non-cirrhosis corpses and comparison of neuron functional protein[J].中国神经再生研究（英文版）,2011,6(29):2273-2278,6.

基金项目

the National Natural Science Foundation of China,No.30872988 （）

中国神经再生研究（英文版）

OACSCDSCI

ISSN：1673-5374

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