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Kongsheng Zhenzhong pill's effect on the learning and memory ability and its neuroprotective effects in vascular dementia rats

Xuming Ji Huayun Yu Bin Ouyang Guowei Liu Zhichun Wu Heng Liu Fang Du

中国神经再生研究（英文版）2011，Vol.6Issue(30)：2342-2346,5.

中国神经再生研究（英文版）2011，Vol.6Issue(30)：2342-2346,5.DOI:10.3969/j.issn.1673-5374.2011.30.004

Kongsheng Zhenzhong pill's effect on the learning and memory ability and its neuroprotective effects in vascular dementia rats

Xuming Ji ¹Huayun Yu ¹Bin Ouyang ¹Guowei Liu ¹Zhichun Wu ¹Heng Liu ²Fang Du³

作者信息

1. College of Basic Medical Science, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong Province, China
2. Otolaryngology Laboratory, Qilu Hospital of Shandong University, Jinan 250012, Shandong Province, China
3. Research Imaging Institute, University of Texas Health Science Center at San Antonio, Texas, USA
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摘要

Abstract

Clinical reports have demonstrated that the Kongsheng Zhenzhong pill (KSZZP), a classical prescriptionderiving from Valuable Prescription for Emergencies, has good therapeutic effects on vascular dementia. However, the mechanisms that mediate its effects remain unclear. In this study,the expression of N-methyl-D-aspartate receptor 1 mRNA, the content of nitric oxide, and the concentrationof calcium in neurons was determined with in situ hybridization, spectrophotometry and flow cytometry, respectively. In addition, the expressions of N-methyl-D-aspartate receptor 1, nervegrowth factor protein, and glial cell line-derived neurotrophic factor protein w ere detected with immunohis tochemistry.We found that KSZZP could significantly decrease the expression of N-methyl-D-aspartate receptor 1 mRNA and protein, the content of nitric oxide, and the concentration of calcium in neurons. KSZZP also increased the expression of nerve growth factor and glialcell line-derived neurotrophic factor protein in the hippocampus CA1 region and in the cerebralcortex. Morris water maze and passive avoidance tests verified that KSZZP ameliorated the cognitiveimpairments of vascular dementia rats. Moreover, the KSZZP-induced improvements in thecognitive functions of vascular dementia rats were correlated with both inhibition of N-methyl-D-aspartate-induced excitable neurotoxicity and elevation of neurotrophic factor expression.

关键词

Kongsheng Zhenzhong pill/vascular dementia/learning and memory ability/neuroprotective effects

Key words

Kongsheng Zhenzhong pill/vascular dementia/learning and memory ability/neuroprotective effects

引用本文复制引用

Xuming Ji,Huayun Yu,Bin Ouyang,Guowei Liu,Zhichun Wu,Heng Liu,Fang Du..Kongsheng Zhenzhong pill's effect on the learning and memory ability and its neuroprotective effects in vascular dementia rats[J].中国神经再生研究（英文版）,2011,6(30):2342-2346,5.

基金项目

a grant from the Young Foundation of Wuhan General Hospital of Guangzhou Military Command of Chinese PLA,No.200810 （）

中国神经再生研究（英文版）

OACSCDSCI

ISSN：1673-5374

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