中国神经再生研究（英文版）2011，Vol.6Issue(30)：2352-2356,5.DOI:10.3969/j.issn.1673-5374.2011.30.006
Baicalin interferes with iron accumulation in C6 glioma cells
Baicalin interferes with iron accumulation in C6 glioma cells
摘要
Abstract
Baicalin reacts with ferric ammonium citrate and acts as an-iron chelator. The maximal reaction time for baicalin to interact with irons was approximately 3 hours. C6 glioma cell survival decreased following iron-loading, with a large number of cells accumulating iron. In addition, lipid peroxidation increased. Iron accumulation and lipid peroxidation were the major cause of cellular death. Baicalin and ferric ammonium citrate alleviated iron accumulation in C6 cells and lowered the mortality of nerve cells. In addition, malondialdehyde and lactate dehydrogenase levels reduced. These results indicate that baicalin strongly inhibits lipid peroxidation via chelation, reduces the content of iron in C6 cells, lowers lipid peroxidation, and thus plays a protective role against iron-induced nerve cell death.关键词
baicalin/iron/iron chelation/neuroprotection/Parkinson's diseaseKey words
baicalin/iron/iron chelation/neuroprotection/Parkinson's disease引用本文复制引用
Chunyan Guo,Xin Chen..Baicalin interferes with iron accumulation in C6 glioma cells[J].中国神经再生研究（英文版）,2011,6(30):2352-2356,5.基金项目
the 2011 Beijing Municipal Commission of Education Science and Technology Development Planning Project,No.KM201110025010 （）
