中国神经再生研究（英文版）2011，Vol.6Issue(32)：2511-2515,5.DOI:10.3969/j.issn.1673-5374.2011.32.006
Role of Toll-like receptor 4 and Janus kinase and signal transducer and activator of transcription signal transduction pathway in sepsis-induced brain damage
Role of Toll-like receptor 4 and Janus kinase and signal transducer and activator of transcription signal transduction pathway in sepsis-induced brain damage
Haiyan Yin 1Jianrui Wei 2Rui Zhang 1Xiaoling Ye 1Youfeng Zhu1
作者信息
- 1. ICU Department,Guangzhou Red Cross Hospital Affiliated to Medical College of Jinan University,Guangzhou 510220,Guangdong Province,China
- 2. Department of Cardiology,Guangzhou Red Cross Hospital Affiliated to Medical College of Jinan University,Guangzhou 510220,Guangdong Province,China
- 折叠
摘要
Abstract
The Janus kinase and signal transducer and activator of transcription (JAK/STAT) signal transduction pathway is involved in sepsis-induced functional damage to the heart, liver, kidney, and other organs.However, the cellular and molecular mechanisms underlying sepsis-induced brain damage remain elusive.In the present study, we found severe loss of neurons in the hippocampal CA1 region in rats with sepsis-induced brain damage following intraperitoneal injection of endotoxin, The expression of toll-like receptor 4, tumor necrosis factor α, and interleukin-6 was significantly increased in brain tissues following lipopolysaccharide exposure.AG490 (JAK2 antagonist) and rapamycin (STAT3 antagonist) significantly reduced neuronal loss and suppressed the increased expression of toll-like receptor 4, tumor necrosis factor α, and interleukin-6 in the hippocampal CA1 region in sepsis-induced brain damaged rats.Overall, these data suggest that blockade of the JAK/STAT signal transduction pathway is neuroprotective in sepsis-induced brain damage via the inhibition of toll-like receptor 4, tumor necrosis factor α, and interleukin-6 expression.关键词
brain damage/Janus kinase and signal transducer and activator of transcription/sepsis/signal transduction pathway/Toll-like receptor 4Key words
brain damage/Janus kinase and signal transducer and activator of transcription/sepsis/signal transduction pathway/Toll-like receptor 4引用本文复制引用
Haiyan Yin,Jianrui Wei,Rui Zhang,Xiaoling Ye,Youfeng Zhu..Role of Toll-like receptor 4 and Janus kinase and signal transducer and activator of transcription signal transduction pathway in sepsis-induced brain damage[J].中国神经再生研究（英文版）,2011,6(32):2511-2515,5.
