武警医学2011，Vol.22Issue(9)：750-753,4.
门静脉减压对大鼠广泛肝切除术后肝功能的保护作用和肝再生的影响
Protective effects of depressing moderately excessive portal pressure on hepatic functions and liver regeneration in extensively hepatectomized rats
张红军 1宗振久 1王曦 1胡永胜 1王义1
作者信息
- 1. 110034,沈阳,武警辽宁总队医院普外科
- 折叠
摘要
Abstract
Objective To evaluate the protective effect of depressing moderately the excessive portal pressure by means of splenic artery ligation and medication on hepatic functions and liver regeneration. Methods One hundred and eighty male Sprague - Dawley rats were divided into four groups: pure hepatectomy (PHx) group, spleen artery ligation (SAL) group, octreotide (OCT) group and prazosin (PRA) group. The incidence of liver failure, survival, liver histology, and pressure of the portal vein were observed in each 85% partially hepatectomized group. Results In treatment group, not only was the portal pressure moderately decreased but liver regeneration was promoted. Gradually increased mitotic figures were observed 24 hours after hepatectomy. There was significant difference between treatment group and pure partial hepatectomy group. Conclusions This is the first time that we have proved that moderate portal decompression not only mitigates liver injury, but also advances liver regeneration to regain valid liver cell population as early as possible to prevent lethal liver failure.关键词
肝切除术/肝再生/门静脉高压/肝损伤/脾动脉结扎术/奥曲肽/哌唑嗪Key words
hepatectomy/ liver regeneration/ portal hypertension/ liver injury/ splenic artery ligation/ octreotide/ prazosin分类
临床医学引用本文复制引用
张红军,宗振久,王曦,胡永胜,王义..门静脉减压对大鼠广泛肝切除术后肝功能的保护作用和肝再生的影响[J].武警医学,2011,22(9):750-753,4.
