中国药理学通报2011，Vol.27Issue(11)：1537-1540,4.DOI:10.3969/j.issn.1001-1978.2011.11.015
中国被毛孢菌丝体提取物抗肾损伤作用体内外实验研究
In vitro and in vivo study of Hirsutella sinensis extract on kidney injury
摘要
Abstract
Aim To investigate the effect of Hirsutella sinensis extract ( HSW ) on kidney injury. Methods The inversion effect of HSW on the renal tubular epithelial cell ( HK2 ) injury caused by aristolochic acid ( AA ) was observed, its influence on functional parameters of renal failure was evaluated and the effect of HSW on acute renal failure ( ARF ) of rats induced by gentamicin was validated. Results HSW deterioratedHK2 cell damage caused by AA, inhibited the upregu-lation of the expression of TGFPj and PAI-1 mRNA, and protected rats from ARF caused by gentamicin. Conclusion HSW had a remarkable action in vitro and in vivo on model of kidney injury.关键词
中国被毛孢菌丝体提取物/体内外作用/肾小管上皮细胞株/细胞损伤/大鼠急性肾衰竭/TGFβ1/PAI-1Key words
Hirsutella sinensis extract/ in vitro and in vivo/ renal tubular epithelial cell/ cell injury/ acute renal failure/ TGFpj/ PAI-1分类
医药卫生引用本文复制引用
沈龙海,安泳潼,杨庆尧,杨晓彤,沈旭,丁宏..中国被毛孢菌丝体提取物抗肾损伤作用体内外实验研究[J].中国药理学通报,2011,27(11):1537-1540,4.基金项目
国家"重大新药创制"科技重大专项资助项目(No 2009ZX09301-007) （No 2009ZX09301-007）
