中国药理学通报2011，Vol.27Issue(11)：1610-1614,5.DOI:10.3969/j.issn.1001-1978.2011.11.032
加巴喷丁对大鼠内脏炎症痛的镇痛作用及机制初步研究
The analgesic effect and mechanism of gabapentin on visceral inflammatory pain in rats
摘要
Abstract
Aim To explore the analgesic effect and mechanism of gabapentin on visceral inflammatory pain in rats. Methods Adult healthy Wistar rats were ran-domly divided into 4 groups: control group, model group,saline group and gabapentin group. Observation: ( 1 ) After model making , 1 5 min was set a time period ,totally 2 h, then visceral pain score was calculated. ( 2 )After model making, 15 min was set a time period, totally 2 h, then firing rate of spinal dorsal horn neurons was recorded. ( 3 ) After model making, at the time point of 30,60 and 120 min, PKC membrane translocation was detected. Results ( 1 ) The pain score in gabapentin group in the former 90 min was significantly lower than that in model group( P < 0. 05 or P <0. 01 ), with no significant difference seen between model group and saline group( P > 0. 05 ). (2 ) After inflammation, the spinal dorsal neuronal firing rate in gabapentin group at the time period of 0 - 15 min and 15-30 min was significantly lower than that in modelgroup at the same period of 0 - 15 min and 15-30 min ( P <0. 01 );no significant difference was seen between model group and saline group( P > 0. 05 ). ( 3 ) PKC membrane translocation in gabapentin group was significantly lower than that in model group( P < 0. 01 or P < 0. 05 ), with no significant difference seen between model group and saline group( P >0. 05 ). Conclusion Gabapentin may have analgesic effect on visceral inflammatory pain through reducing PKC membrane translocation and inhibiting PKC activation.关键词
加巴喷丁/内脏/炎症痛/蛋白激酶C/膜转位/疼痛评分/放电频率Key words
gabapentin/ viscera/ inflammatory pain/ protein kinase C/ membrane translocation/ pain score/ discharge frequency分类
医药卫生引用本文复制引用
张继国,张颜波,杨明峰,高允生..加巴喷丁对大鼠内脏炎症痛的镇痛作用及机制初步研究[J].中国药理学通报,2011,27(11):1610-1614,5.基金项目
山东省高等学校科技计划资助项目(No J10LF14) （No J10LF14）
