临床神经病学杂志2011，Vol.24Issue(5)：384-386,3.
经颅多普勒超声持续监测辅助尿激酶动脉溶栓治疗急性脑梗死的疗效观察
Observation of curative effects of urokinase intra-arteriai thrombolysis combined with continuous monitoring of transcraniai doppler on acute cerebral infarction
摘要
Abstract
Objective To observe the curative effects of urokinase intra-arterial thrombolysis combined with continuous monitoring of transcranial doppler (TCD) on acute cerebral infarction. Methods Twenty-eight patients with acute cerebral infarction were randomly divided into TCD group and control group. The therapy of urokinase intra-arterial thrombolysis was used to treat the patients of the two groups. And the patients of TCD group were given continuous monitoring of TCD. The condition of vascular recanalization was judged by the change of blood flow signal -of TCD. The degree of neurologic impairment was evaluated by National Institutes of Health Stroke Scale ( NIHSS) and Barthel index ( BI). During 3 d after the treatment, CT was used to detect whether there be adverse reaction like intracranial hemorrhage or not. Results At 30 d, 90 d after the treatment, the NIHSS scores of TCD group were significantly lower than control group (all P <0.05) ; while the BI were significantly higher than control group (P < 0. 05 -0.01). The vascular recanalization rate of TCD group (78.6% ) at 24 h after the treatment was significantly higher than control group ( 30. 8 ) (P < 0. 05 ). And the vascular recanalization time of TCD group [ (34. 5 ± 10. 5) min ] after treatment was significantly shorter than contral group [(55.8 ±13.6) min ] ( P < 0. 01). No adverse reaction like intracranial hemorrhage and so on was found by CT detection during 3 d after the treatment in the two groups. Conclusion The curative effects of urokinase intra-arterial thrombolysis combined with continuous monitoring of TCD on acute cerebral infarction is good, and there is no obvious adverse reaction.关键词
经颅多普勒超声/尿激酶/动脉溶栓/急性脑梗死Key words
trancranial doppler/ unokinase/ intra-arterial thrombolysis/ acute cerebral infarction分类
医药卫生引用本文复制引用
谢坚,罗韶辉,侯小兵..经颅多普勒超声持续监测辅助尿激酶动脉溶栓治疗急性脑梗死的疗效观察[J].临床神经病学杂志,2011,24(5):384-386,3.基金项目
佛山市医疗卫生科研计划课题(2010051) （2010051）
