中国医科大学学报2011，Vol.40Issue(9)：794-796,3.DOI:CNKI:21-1227/R.20110926.1209.033
微血管计数和侵入在肾细胞癌中的表达及意义
Expression and Significance of Microvessel Count and Microvascular Invasion in Renal Cell Carcinoma
摘要
Abstract
Objective To investigate the relationship between tumor angiogenesis, microvascular invasion and the pathological staging,subsequent development of metastatic disease in patients who were undergone surgery for renal cell carcinoma (RCC). Methods Immunohis-tochemical method was used to detect Factor VDI and CD34 which decorated endothelial cells in order to assess microvessel count and mi-crovascular invasion and their relevance for developing metastatic disease in 88 cases of RCC. A retrospective analysis of the pathological staging and the development of metastatic disease was made. Patients was taken a follow-up visit of more than 4 years and divided into two groups:recidivation group and unrecidivation group. Results When Factor VDI-related antigen staining was used,we found that the microvessel count correlated with the development of metastatic disease,with a mean count of 52.3 and 96.6 for patients who had non-developed and developed metastatic disease (P < 0.01),respectively. We also found that microvascular invasion correlated with the development of metastatic disease. It was demonstrated that 76.5% of patients who developed metastatic disease versus 42.3% of patients with no evidence of metastasis with Factor VDI staining (P< 0.01) were positive,and 47.1% versus 18.3% with CD34 staining were positive,respectively (P< 0.05). Conclusion Microvessel count and microvascular invasion in RCC might be a predictor of tumor aggression,for the patient who had easily got recidivation should have an enhanced follow-up visit,the targeted therapy or other adjuvant therapy should be taken into account early.关键词
微血管计数/肾细胞癌/侵入/转移Key words
microvessel count/renal cell carcinoma/microvascular invasion/metastatic分类
医药卫生引用本文复制引用
张慕淳,张赟,王金辉,王永刚,高吉,马天武,温建平,孔祥波..微血管计数和侵入在肾细胞癌中的表达及意义[J].中国医科大学学报,2011,40(9):794-796,3.基金项目
吉林省科技厅基金资助项目(20100736) （20100736）
