临床肝胆病杂志2011，Vol.27Issue(9)：939-943,5.
STAT3,Survivin在胆囊癌中的表达及意义
Significance and expression of STAT3 in survivin primary gallbladder carcinoma
摘要
Abstract
Objective To detect the expression of STAT3 , p - STAT3 and Survivin in primary gallbladder carcinoma (PGC) and explore its significance in the occurrence and development of PGC. Methods The expression of STAT3, p - STAT3 and Survivin were determined in samples from 45 PGC tissues and corresponding nontumor tissues, 20 chronic cholecystitis by immunohistochemistry. The relationship between expressions of these proteins and clinicopathological factors, and its prognosis were analysed. Results The positive rates of STAT3, p - STAT3 and Survivin in 45 PGC tissues were 66.7% (30/45), 55.6% (29/45) and 64% (25/45) respectively, which was significantly higher than those in 45 corresponding PGC nontumor tissues (P < 0.01) and 20 chronic cholecystitis tissues (P < 0.01). The expression of survivin were positively correlated with STAT3(r =0.558, P <0.01), p - STAT3( r =0.830, P <0.01). The expressions of STAT3, p -STAT3 and Survivin were significantly associated with histopathological grades, lymph node metastasis, nevin stages and 3 - year survival rate. Conclusion STAT3, p - STAT3 and Survivin may play a vital role in the occurrence and development of PGC. The expressions of STAT3, p - STAT3 or Survivin are the metastatic and prognostic factors in PGC.关键词
胆囊肿瘤/STAT3转录因子/凋亡抑制蛋白质类Key words
gallbladder neoplasms/ STAT3/ transcription factor/ inhibitor of apoptosis分类
医药卫生引用本文复制引用
杨卫富,李德春,印山河..STAT3,Survivin在胆囊癌中的表达及意义[J].临床肝胆病杂志,2011,27(9):939-943,5.基金项目
南京市科技发展项目(YKK09193) （YKK09193）
