实用医学杂志2011，Vol.27Issue(21)：3872-3874,3.DOI:10.3969/j.issn.1006-5725.2011.21.017
腺苷后适应对糖尿病急性心肌梗死再灌注的保护作用
Adenosine postconditioning protects against ischemic-reperfused myocardium of acute myocardial infarction with diabetes
摘要
Abstract
Objective To investigate the protective effect of adenosine postconditioning on ischemicreperfused myocardium of acute myocardial infarction with diabetes during percutaneous coronary intervention (PCI). Methods The 84 patients with acute myocardial infarction (AMI) were divided into 6 groups: non-diabetic ischemic-reperfused (IR) group, non-diabetic postconditioning (POST) group, diabetic ischemic-reperfused (DIR) group, diabetic postconditioning (DPOST) group. The diabetic groups were further divided into DIR1 (HbA1c < 7%), DIR2(HbA1c ≥ 7%), DPOST1 (HbA1c < 7%), DPOST2 (HbA1c ≥ 7%) groups according to their HbA1c after admission. Adenosine was intravenously given in POST and DPOST groups before the stent was implanted. The same amount normal saline was given in IR and DIR groups. Coronary serum MDA and SOD were detected before PCI and 30 minutes later after PCI. Serum CK-MB was detected respectively 6 hours, 12 hours, 24 hours and 48 hours later after PCI. Results The level of MDA was significantly increased, but the level of SOD was significantly decreased in all the six groups after the operation (P < 0.01). The level of MDA in POST group and DPOST groups is lower than that in IR group and DIR groups (P < 0.05), but the level of SOD is higher (P < 0.05) after PCI. The peak value of CK-MB of POST group and DPOST groups is significantly increased compared to IR group and DIR groups after PCI (P < 0.05). Conclusion PCI combined with adenosine postconditioning treatments can alleviate ischemic-reperfused myocardial injury of patients with AMI and diabetes.关键词
腺苷/后适应/糖尿病/急性心肌梗死/心肌缺血再灌注损伤Key words
Adenosine/Postconditioning/Diabetes/Acute myocardial infarction/Ischemicreperfused myocardial injury引用本文复制引用
王芳,吴红玲,王执兵,凌云..腺苷后适应对糖尿病急性心肌梗死再灌注的保护作用[J].实用医学杂志,2011,27(21):3872-3874,3.基金项目
深圳市南山区卫生科技计划项目基金资助(编号:2009017) （编号:2009017）
