临床肝胆病杂志2011，Vol.27Issue(10)：1116-1120,5.
高迁移率族蛋白B1在肝脏疾病发生中的作用
The role of high mobility group box 1 in human liver diseases
摘要
Abstract
High mobility group box 1 ( HMGB1) is an enriched non - histone, chromatin - associated nuclear protein. During cell damage and inflammation HMCB1 can be extracellularly released by ways of active secretion and passive diffusion. Recent studies shows that HMGB1 may act as an inflammatory factor and an endogenous damage - associated molecular pattern recognized by its receptors, mediates liver inflammation, injury, fibrogenesis, as well as oncogenesis and tumor immune response. This review introduces the structure, function of HMGB1 and its role in human liver diseases.关键词
肝疾病/HMGB1 蛋白质Key words
liver diseases/ HMGB1 protein分类
医药卫生引用本文复制引用
张哲,郭津生..高迁移率族蛋白B1在肝脏疾病发生中的作用[J].临床肝胆病杂志,2011,27(10):1116-1120,5.基金项目
国家自然科学基金(81070340) （81070340）
