山东医药2011，Vol.51Issue(35)：28-30,3.
胆管癌组织中Survivin和Caspase-3蛋白 表达及与预后的关系
Expression of Survivin and Caspase-3 protein and their correlation with prognosis in patients with cholangiocarcinoma
许鹏 1黄强 1刘臣海 1谢放 1邵峰1
作者信息
- 1. 安徽医科大学附属省立医院,合肥230001
- 折叠
摘要
Abstract
Objective To explore the expression of Survivin and Caspase-3 protein and their clinicopathological signi-cance in patients with cholangiocarcinoma. Methods The immunohistochemical method was used to analyze the Survivin and Caspase-3 protein expression in 57 cases of cholangiocarcinoma and 23 cases of adjacent noncancerous normal bile duct tissues. The correlation between the expression of Survivin and Caspase-3 protein with the clinicopathological features and prognosis were analyzed. Results The Survivin expression in cholangiocarcinoma was significantly higher than that in adjacent noncancerous normal bile duct tissues, but the Caspase-3 protein expression was on the contrary (both P < 0.05); the expression of Survivin and Caspase-3 protein were related with differentiation grade, TNM stage and lymphnode metastas (both P<0.05) ; there was inverse correlation bewteen the expression of Survivin and Caspase-3 protein (P=0.001,r = -0.415); The kaplan-Meier analysis showed that the overall survival time of patients positively expressed Survivin was significantly shorter than that of patients negatively expressed Survivin, but the Caspase-3 protein expression was on the contrary (both P<0.05); by Cox regression analysis,the Survivin expression was an independent prognostic factor(P< 0.05). Conclusions The high expression of Survivin and low expression of Caspase-3 protein may be a synergistic effect in the progression of cholangiocarcinoma.关键词
胆管肿瘤/Survivn蛋白/Caspase-3蛋白Key words
bile duct tumor/ Survivin protein/ Caspase-3 protein分类
医药卫生引用本文复制引用
许鹏,黄强,刘臣海,谢放,邵峰..胆管癌组织中Survivin和Caspase-3蛋白 表达及与预后的关系[J].山东医药,2011,51(35):28-30,3.
