山东医药2011，Vol.51Issue(35)：31-33,3.
放疗对耳蜗组织结构及脂质过氧化产物抗氧化酶的影响
Effect of irradiation on the damage of cochlear and lipid peroxidation/antioxidant enzyme
摘要
Abstract
Objective To explore the mechanism of sensorineural hearing loss after irradiation. Methods Sixty-six guinea pigs were randomly divided into observed group(60 guinea pigs) and control group(6 guinea pigs). The right ears of observed group were given irradiation, 10 guinea pigs were sacrificed at 1, 4, 7, 14 and 30 days after irradiation. The control group was given no irradiation. The specimens were dehydrated, embeded in paraffin and serially cutted. Sections were stained with haematoxylin and eosin for light microscopic examination, and the level of malondialdehyde (MDA) and activity of supperoxide dismutase ( SOD) were examined. Results Inner ear damage was found in the observed group after irradiation, the level of MDA in observed group was significantly higher than that in control group, but the activity of SOD was significantly lower than that in control group. Conclusions Irradiation might cause cochlear cell damage, increse of MDA and decrease of SOD; this may be the mechanism of sensorineural hearing loss.关键词
放射治疗/神经性耳聋/丙二醛/超氧化物酶/耳蜗Key words
irradiation/ sensorineural hearing loss/ malondialdehyde/ supperoxide dismutase/ inner ear分类
医药卫生引用本文复制引用
谢利红,唐安洲,尹时华,谭颂华..放疗对耳蜗组织结构及脂质过氧化产物抗氧化酶的影响[J].山东医药,2011,51(35):31-33,3.基金项目
广西壮族自治区自然科学基金资助项目(桂科字0832126). （桂科字0832126）
