解剖学杂志2011，Vol.34Issue(5)：576-579,4.
神经调节素β1对P3大鼠缺氧性脑白质损伤的保护作用
Protective effects of neuregulin β1 on white matter damage in P3 hypoxia-ischemial neonatal rats
摘要
Abstract
Objective: To investigate the protective effects of neuregulin β1 (NRG β1) on periventricular white matter damage (PWMD) in P3 neonatal rats. Methods: P3 Sprague-Dawley (SD) neonatal rats were randomized into a sham operation group, hypoxic-ischemic (HI) group, and NRG β1 group. The physical development and neural behavior were evaluated. The MBP expression in white matter of P7 , P14 and P21 rat pups in 3 groups were studied by Western blot Results: NRG β1 improved physical development (body weight gained and eye opening) and neurobehavioral performance (cliff avoidance) of HI injuried rat pups, and the difference was statistically significant NRG β1 improved MBP expressions in P7, P14 and P21 rat pups of HI injured group respectively, and the difference was statistically significant Conclusion:NRG β1 increases the synthesis of MBP and improves neurological functions following cerebral hypoxia-is-chemia in the P3 neonatal rat关键词
神经调节素β1/缺氧-缺血/髓鞘碱性蛋白/脑白质损伤Key words
neuregulin β1/hypoxia-ischemia/myelin basic protein/periventricular white matter damage引用本文复制引用
周琳瑛,王玮,高美钦,林曦..神经调节素β1对P3大鼠缺氧性脑白质损伤的保护作用[J].解剖学杂志,2011,34(5):576-579,4.基金项目
福建省科技厅高校三项费基金(2007F5054) （2007F5054）
