吉林农业大学学报2011，Vol.33Issue(5)：576-580,5.DOI:22-1100/S.20110707.0940.001
硝唑尼特的一般毒性和致突变性研究
General Toxicity and Mutagenicity of Nitazoxanide
摘要
Abstract
The general toxicity of nitazoxanide was investigated by acute toxicty test, accumulative toxicity and tolerance test of mice; the mutagenicity of nitazoxanide was evaluated by Ames test, marrow cell mi-cronucleus test and sperm malformation test of mice. The results showed that mice acute oral LD50 of nitazoxanide was 6.295 g/kg, belonging to no toxic substance. The 20 d administration accumulation coefficient was K > 5.26 which demonstrated that nitazoxanide was low or not accumulated. Through the Ames test, micronucleus test and sperm malformation test, nitazoxanide was not found to have any mutagenicity.关键词
硝唑尼特/急性毒性/蓄积毒性/致突变性Key words
nitazoxanide/ acute toxicity/ accumulative toxicity/ mutagenicity分类
农业科技引用本文复制引用
张德利,吴永魁,张瑞岩,李乾学,张西臣..硝唑尼特的一般毒性和致突变性研究[J].吉林农业大学学报,2011,33(5):576-580,5.基金项目
国家“十一五”科技支撑计划项目(2006BAD31804) （2006BAD31804）
