内科理论与实践2011，Vol.6Issue(4)：279-282,4.
肥胖青少年患者血清肝型脂肪酸结合蛋白水平及其相关因素分析
Serum liver-type fatty acid binding protein level and related factors in obese young adults
石娟 1李小英 1王卫庆 1宁光 1洪洁 1张翼飞 1顾卫琼 1崔斌 2徐敏 1晏群 1翟莹 1王莉 1李丽娟1
作者信息
- 1. 上海交通大学医学院附属瑞金医院内分泌代谢病科 上海市内分泌代谢病临床中心，上海200025
- 2. 中国科学院上海市健康科学研究所，上海200025
- 折叠
摘要
Abstract
Objective To asses the serum liver-type fatty acid binding protein (L-FABP or FABP1) level in Shanghai obese young adults under different glucose metabolism and study the relationship between serum L-FABP level and glucose metabolism, lipid metabolism and pancreatic β-cell function. Methods A total of 267 subjects were enrolled in this study including subjects with normal glucose tolerance (NGT, n=107), impaired glucose regulation (IGR, n=118) and type-2 diabetes mellitus (T2DM, n=42). Serum L-FABP level was detected by enzyme-linked immunosorbent assay (ELISA). Meanwhile, pancreatic β-cell function was assessed by ΔI30/ΔG30 and by acute insulin response to glucose (AlRg). Results After adjustment for age, gender and body mass index (BMI), the serum L-FABP level in IGR and T2DM was significantly higher than that in NGT (P<0.001), but there was no statistical difference in serum L-FABP level between IGR and T2DM. Correlation analysis showed that serum L-FABP level was significantly correlated to triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C), fasting blood glucose (FBG) and 2-hour plasma glucose (2 hPG) (P<0.05) before and after adjustment for age and BMI. Multiple step-wise regression analysis showed that 2 hPG was an independent factor related to serum L-FABP level. In 267 subjects, correlation analysis did not show any correlation between serum L-FABP level and ΔI30/ΔG30. In 162 subjects (65 NGT, 73 IGR and 24 T2DM), serum L-FABP level was shown to be not related to AIRg. Conclusions Serum L-FABP level increased significantly in obese subjects with abnormal glucose homeostasis. Serum L-FABP level was correlated with glucose and lipid metabolism, but not with pancreatic B-cell function.关键词
肥胖症；糖调节受损；糖尿病；肝型脂肪酸结合蛋白；脂代谢Key words
Obesity/ Impaired glucose regulation/ Diabetes mellitus/ Liver-type fatty acid binding protein/ Lipid metabolism分类
医药卫生引用本文复制引用
石娟,李小英,王卫庆,宁光,洪洁,张翼飞,顾卫琼,崔斌,徐敏,晏群,翟莹,王莉,李丽娟..肥胖青少年患者血清肝型脂肪酸结合蛋白水平及其相关因素分析[J].内科理论与实践,2011,6(4):279-282,4.
