解剖学杂志2011，Vol.34Issue(5)：649-652,4.
电针对帕金森病模型大鼠的作用
Effect of electroacupuncture on the Parkinson's disease model rats
摘要
Abstract
Objective: To explore the effect of electroacupuncture (EA) with different frequency in different time course on postural asymmetry and expression of tyrosine hydroxylase in substantia nigra pars (SNc) of Parkinson's disease (PD) model rats. Methods: Sprague-Dawley rats were randomly divided into normal control, sham, model, Madopar treatment, low-frequency and high-frequency EA groups. According to treatment course (1,2 and 3 weeks), the later five groups were subdivided into three subgroups. The PD model was duplicated by injecting 6-hydroxyl-dopamine (6-OHDA) into the right stria-tum of rats. And, the rats in EA groups were given low-frequency (2 Hz) and high-frequency (100 Hz) at "Hegu" and "Taichong" points. The postural asymmetry was observed, and the expression of TH in SNc was detected immunohisto-chemially. Results:High-frequency EA suppressed the increased rotation frequency to the right side that was showed in model rats. Additionally, high-frequency EA caused an up-regulation of TH expression in SNc, which was reduced in PD models. However, these effects were not observed in animals treated with low-frequency EA. Conclusion: This finding suggest that high-frequency EA has a therapeutic effect in the PD rats, attributing to its capability to reduce the rotational frequency to the lesioned side and up-regulate the TH expression in SNc.关键词
帕金森病/黑质/酪氨酸羟化酶/电针Key words
Parkinson's disease/substantia nigra/tyrosine hydroxylase/electroacupuncture引用本文复制引用
倪进忠,丁艳霞,熊克仁..电针对帕金森病模型大鼠的作用[J].解剖学杂志,2011,34(5):649-652,4.基金项目
皖南医学院中青年科研基金(WK200917) （WK200917）
