天然产物研究与开发2011，Vol.23Issue(5)：805-808,4.
青龙衣中细胞毒活性成分的研究
Chemical Constituents of Pericarpium Juglantis
摘要
Abstract
Eleven compounds were isolated from Pericarpium Juglantis.and their structures were identified as 2-hydroxy-1,4-naphthoquinone (1) ,5-hydroxy-l ,4-naphthoquinone (2) ,2,5-dihydroxy-l ,4-naphthoquinone (3) ,2,5-dihydroxy-1,4-naphthoquinone (4) ,2,5-dihydroxy-l ,4-naphthoquinone (5) ,5-methoxy-l ,4-naphthoquinone (6) ,5,7-dihydroxy-chromone (7) .isovanillic acid (8) .gallic acid (9) ,/3-sitosterol (10) ,and/3-daucosterol (11). by means of their physic-chemical properties and spectroscopic ways. In the cytotoxic assay,3 and 4 exhibited significant inhibitory effects a-gainst HepG2 cancer cell lines with IC50 value of 5.0 ±0.6 umol/L and 7.0 ±0.5 umol/L,respectively. And 2 and 5 showed significant inhibitory effects against HL-60 cancer cell lines with IC50, value of 9. 3 ± 1.2 umol/L和2. 3 ± 0.2 umol/L,respectively.关键词
青龙衣/化学成分/萘醌类/结构鉴定/细胞毒活性Key words
Juglans mandshurica/ chemical constituents/ structural identification/ cytotoxic activity分类
医药卫生引用本文复制引用
董梅,袁日,齐凤琴,李廷利..青龙衣中细胞毒活性成分的研究[J].天然产物研究与开发,2011,23(5):805-808,4.基金项目
黑龙江省教育厅科学技术研究项目(11541162) （11541162）
