天然产物研究与开发2011，Vol.23Issue(5)：828-832,5.
壳聚糖微球分散体系的抑菌性研究
Antibacterial Activities of Chitosan Microspheres
摘要
Abstract
The chitosan microspheres ( CMs) were prepared via emulsion chemical cross-linking method. The antibacterial activities of CMs with different concentrations and different diameters against Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25992 were investigated,and the inhibition mechanisms were also discussed. The results indicated that the antibacterial activities increased with the increasing of concentration and the decreasing of diameter of CMs. The CMs could inhibit the growth of the bacteria in the initial stage and then promote it when the concentration was lower than 0.7 mg/mL. Trie CMs exhibited the bactericidal effect completely when the concemtration was higher than 0.7 mg/ mL. The minimum inhibitory concentrations and the minimum bactericidal concentrations were 0. 8 mg/mL and 1.4 mg/ mL respectively for 5. aureus and 1. 0 mg/mL and 1. 8 mg/mL respectively for E. coli. The results showed that CMs could inhibit the growth of the Cram-positive and Gram-negative bacteria effectively, and the Gram-positive bacteria were more sensitive than Gram-negative bacteria. The SEM images showed that the bacteria could adhere to CMs quickly with obviously morphology changing.关键词
壳聚糖微球/乳化交联法/抑菌活性Key words
chitosan microspheres/emulsion chemical cross-linking method/antibacterial activities分类
化学化工引用本文复制引用
任丽宏,陈西广,程晓杰,周旋,孔明..壳聚糖微球分散体系的抑菌性研究[J].天然产物研究与开发,2011,23(5):828-832,5.基金项目
国家自然科学基金资助项目(NSFC 81071274) （NSFC 81071274）
