天然产物研究与开发2011，Vol.23Issue(5)：842-845,852,5.
天麻酯溶性酚性成分对大鼠脑缺血/再灌注损伤的保护作用
Protective Effect of Esterified Phenolic Compounds from Gastrodia elata Blume.on Cerebral Ischemia-reperfusion Iniury
摘要
Abstract
The main aim was to investigate the protective effect of esterifled phenolic compounds from Gastrodia elata Blume. on cerebral ischemia-reperfusion injury. The middle cerebral artery occlusion ( MCAO) model was used. The neurological score,infarct volume,brain tissue water content, and brain tissue Calmodulin-dependent proteinkinase II ( CaMK II) expression were evaluated. The results showed that esterified phenolic compounds of G. elata could significantly improve the neurological symptoms,reduce infarct volume and cerebral edema,regulate the expression of CaMK II. Esterified phenolic compounds of G. elata had a significant protective effect on cerebral ischemia-reperfusion injury.关键词
天麻/酯溶性酚性成分/脑缺血/再灌注Key words
Gastrodia elata Blume. /ethyl acetate extract/cerebral ischemia-reperfusion分类
医药卫生引用本文复制引用
李秀芳,孙衍鲲,张维明,段小花,代蓉,林青..天麻酯溶性酚性成分对大鼠脑缺血/再灌注损伤的保护作用[J].天然产物研究与开发,2011,23(5):842-845,852,5.基金项目
国家自然科学基金项目(30760305) （30760305）
云南省应用基础研究计划面上项目(2007C076M) （2007C076M）
