南方医科大学学报Issue(9)：1551-1555,5.
MACC1、HGF和C-met蛋白在卵巢上皮性癌中的表达及其意义
Expressions of MACC1, HGF, and C-met protein in epithelial ovarian cancer and their significance
摘要
Abstract
Objective To investigate the expressions of metastasis-associated in colon cancer-1 (MACC1), hepatocyte growth factor (HGF), and C-met proteins in epithelial ovarian cancer and their significance. Methods The expressions of MACC1, HGF and C-met in 20 specimens of normal ovarian tissues, 19 specimens of benign epithelial ovarian tumor and 52 specimens of epithelial ovarian cancer were measured by irnmunohistochemistry and Western blotting. The correlations of the expressions of MACC1, HGF and C-met protein to the clinicopathologic characteristics of epithelial ovarian cancer were analyzed, and the correlations between the expressions of the 3 proteins were also evaluated. Results The positivity rates of MACC1, HGF and C-met proteins were 73.1%, 63.5% and 78.8% in epithelial ovarian cancer with relative expressions of 0.72 ±0.05, 0.64 ±0.04 and 0.79 ±0.04, respectively, showing significant differences from those in normal ovarian tissues and benign ovarian tumors (P<0.05). In epithelial ovarian cancer, the up-regulation of MACC1, HGF and C-met expressions were associated with advanced FIGO stage, poor differentiation and lymph node metastasis (P<0.05). MACC1 expression was positively correlated to HGF (r=0.350, P= 0.011) and C-met expressions (r=0.429, p=0.002), and the latter two was also positively correlated (r=0.487, P=0.000). Conclusions MACC1 may serve as a potential biomarker for advanced ovarian cancer. Deregulation of MACC1, HGF and C-met proteins may synergistically participate in the malignant progression of epithelial ovarian cancer.关键词
卵巢肿瘤/上皮性癌/MACC1/HGF/C-metKey words
ovarian neoplasm, epithelial cancer/ metastasis-associated in colon cancer-1/ hepatocyte growth factor/C-met分类
医药卫生引用本文复制引用
张瑞涛,史惠蓉,黄好亮,陈志敏,刘惠娜,苑中甫..MACC1、HGF和C-met蛋白在卵巢上皮性癌中的表达及其意义[J].南方医科大学学报,2011,(9):1551-1555,5.基金项目
河南省教育厅自然科学研究计划(2011 A320045) （2011 A320045）
