南方医科大学学报Issue(9)：1560-1563,4.
肿瘤翻译调控蛋白在人乳腺癌组织中的表达及临床意义
Expression of translationally controlled tumor protein in human breast cancer and its clinical significance
摘要
Abstract
Objective To investigate the expression of translationally controlled tumor protein (TCTP) in human breast cancer tissues and its clinical significances. Methods The expression of TCTP in 94 human breast cancer and the corresponding adjacent normal mammary tissues were detected using immunohistochemistry. Results The expression rate of TCTP was 64.89% in human breast cancer tissues, significantly higher than that in normal benign mammary tissues (39.36%, P<0.001). TCTP overexpression was positively correlated to the tumor size, clinical stage, lymph node metastasis and histological grade of breast cancer (P<0.05). Patients with positive TCTP expression had a significantly shorter mean survival time than those with negative expression (P<0.001). Conclusion TCTP may play an important role in the tumorigenesis and development of breast cancer, and can be an important prognostic factor for this malignancy.关键词
乳腺癌/肿瘤翻译控制蛋白Key words
breast cancer/ translationally controlled tumor protein分类
生物科学引用本文复制引用
李嗣杰,贾泓瑶,吴迪,范志民..肿瘤翻译调控蛋白在人乳腺癌组织中的表达及临床意义[J].南方医科大学学报,2011,(9):1560-1563,4.基金项目
吉林省自然科学基金(201015155) （201015155）
吉林大学基本科研业务费资助课题(421030170428) （421030170428）
