南方医科大学学报Issue(9)：1571-1574,4.
18F-FDG符合线路显像对甲状腺乳头状癌颈部淋巴结转移131Ⅰ疗效的预测价值
Value of 18F-FDG dual head coincidence imaging in predicting the efficacy of radioiodine therapy for papillary thyroid carcinoma with cervical lymph node metastasis
摘要
Abstract
Objective To assess the value of 18F-FDG dual head coincidence imaging in the prediction of the efficacy of radioiodine therapy in patients with cervical lymph node (LN) metastasis of papillary thyroid carcinoma (PTC). Methods Thirty-six patients undergoing thyroidectomy and radioiodine ablation of the residual normal thyroid tissue received "F-FDG dual head coincidence imaging and then therapeutic 131I-whole body imaging (131I-WBI) in the same week. According to those imaging results, the patients were divided into group I with positive results of both imaging examinations and group II with positive results by 131I-WBI but negative results byl8F-FDG dual head coincidence imaging. All the patients were followed up for 6 months. Results In group I (14 patients), a total of 49 lesions were diagnosed as cervical LN metastases, and the total sensitivity differed significantly between 18F-FDG dual head coincidence imaging and 131I- WBI (67.3% vs 89.8%, P=0.027). In both groups, the total sensitivity of 18F-FDG dual head coincidence imaging and mI-WBI showed a significant difference (26.0% vs 94.5%, P<0.001). The target and non-target ratio (T/NT) was identified as one of the factors affecting the radioiodine efficacy (P<0.001). In group II (22 patients), 76 lesions were diagnosed as cervical LN metastases. The effective rates of groups I and II were 35.7% and 81.8%, respectively, showing a significant difference between them (P=0.011). Conclusion 131I-WBI is more sensitive than I8F-FDG dual head coincidence imaging in detecting cervical LN metastasis in patients with PTC. Patients with cervical LN metastases who have positive results in both 131I-WBI and 18F-FDG dual head coincidence imaging tend to have a poorer response to the therapy than the patients with negative results in l8F-FDG dual head coincidence imaging. The T/NT of the cervical LN metastases in 18F-FDG dual head coincidence imaging is associated with the efficacy of radioiodine therapy.关键词
脱氧葡萄糖/符合线路/甲状腺肿瘤/放射疗法/碘放射性同位素/淋巴转移Key words
deoxyglucose/ coincidence/ thyroid neoplasms/ radiotherapy/ iodine radioisotopes/ lymphatic metastasis分类
医药卫生引用本文复制引用
孙云钢,冯会娟,刘金华,胡瑞,欧阳伟..18F-FDG符合线路显像对甲状腺乳头状癌颈部淋巴结转移131Ⅰ疗效的预测价值[J].南方医科大学学报,2011,(9):1571-1574,4.基金项目
卫生部重点课题专项分题(W2009BX002) （W2009BX002）
