南方医科大学学报Issue(9)：1632-1634,3.
25例显微型多血管炎临床与病理分析
Clinical and pathological analysis of 25 cases of microscopic polyangiitis
刘宏发 1任昊 1王国保1
作者信息
- 1. 南方医科大学南方医院肾内科，广东广州510515
- 折叠
摘要
Abstract
Objective To analyze the clinical and pathological features of microscopic polyangiitis (MPA) to improve the diagnosis and treatment of the disease. Methods Twenty-five cases of MPA were retrospectively analyzed. Results The onset symptoms of MPA, often nonspecific, included fever, muscle and joint pain, fatigue, loss of weight, etc, with varying degrees of proteinuria, hematuria and renal insufficiency. The pathological types revealed by renal biopsy were mainly focal segmental necrotizing glomerulonephritis or pauci-immune crescentic glomerulonephritis. Timely immunosuppressive therapy could improve the outcome. Conclusion The early symptoms of MPA are often nonspecific to easily result in misdiagnosis. Examination of ANCA titers and timely renal biopsy are helpful to establish an early diagnosis. Immune suppression therapy and plasma exchange when necessary should be initiated after the establishment of the diagnosis. The disease activity and drug toxicity should be carefully monitored to improve the prognosis.关键词
显微型多血管炎/新月体性肾小球肾炎/局灶节段坏死性肾小球肾炎Key words
microscopic polyangiitis/ crescentic glomerulonephritis/ focal segmental necrotizing glomerulonephritis分类
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刘宏发,任昊,王国保..25例显微型多血管炎临床与病理分析[J].南方医科大学学报,2011,(9):1632-1634,3.
