兰州大学学报（医学版）2011，Vol.37Issue(3)：49-53,57,6.
连续静-静脉血液透析滤过在重症急性胰腺炎治疗中的内环境稳态维持作用
Application of continuous veno-venous hemodiafiltration in the treatment of acute severe pancreatitis to maintain the stable state of internal environment
摘要
Abstract
Objective To study the efficacy and mechanisms of continuous veno-venous hemofil-tration (CVH) in treatment of severe acute pancreatitis. Methods 58 cases of severe acute pancreatitis patients were enrolled: 33 patients treated with CVH, as the experimental group; 25 patients received comprehensive medical treatment as a control group. At the time points of 0, 24, 72 h during the treatment, two groups' tumor necrosis factor (TNF), interleukin-1, 2, 6 (IL-1, IL-2, IL-6), serum creatinine, serum bilirubin Su, serum amylase, urine amylase, blood urea nitrogen were detected accordingly. Results Among 58 patients, 28 cases were cured, 3 patients died in the experimental group because of multiple organ failure, and 2 patients were discharged for other reasons. The other patients tolerated the treatment well and there was no bleeding during the treatment of imbalance symptoms and no serious hypotension as well. Among 25 cases of the control group, 20 cases were cured, 4 patients died, 1 patient left the hospital for other reasons, compared with before, after 24 h treatment serum cytokines' TNF, IL-6 levels of the two groups were significantly lower (P <0.01), and they decreased more significantly in the experimental group (P <0.05) than in the control group; compared with the control group, after 72 h treatment, CVH patients' IL-1, IL-2 decreased significantly (P <0.05), and their serum bilirubin Su, serum amylase index decreased significantly (P <0.05), and still their serum creatinine also decreased significantly (P <0.01). Conclusion The early application of CVH in the treatment of severe acute pancreatitis is an effective means to rescue one of severe acute pancreatitis.关键词
重症急性胰腺炎/连续静-静脉血液透析滤过/血液净化/内环境Key words
severe acute pancreatitis/ continuous veno-venous hemofiltration/ blood purification分类
医药卫生引用本文复制引用
毛杰,李梅,王俭勤,宋爱琳,陈晓,王文革,董晨明,张有成..连续静-静脉血液透析滤过在重症急性胰腺炎治疗中的内环境稳态维持作用[J].兰州大学学报（医学版）,2011,37(3):49-53,57,6.基金项目
兰州市科技计划项目(2008-1-82) （2008-1-82）
兰州大学第二医院科研项目(YJ2007-12) （YJ2007-12）
