兰州大学学报（医学版）2011，Vol.37Issue(3)：71-75,5.
原发帕金森病全脑灰质结构基于体素的MRI形态学分析
A whole-brain gray matter analysis in patients with Parkinson's disease from voxel-based MRI morphometry
张静 1张云亭 2张本恕 3杨俊峰3
作者信息
- 1. 兰州大学第二医院放射科,兰州730030
- 2. 天津医科大学总医院放射科,天津300052
- 3. 天津医科大学总医院神经内科,天津300052
- 折叠
摘要
Abstract
Objectives To analyze the structural changes of whole brain gray matter in Parkinson's disease from voxel-based morphometry (VBM). Methods 35 Parkinson's disease patients and 20 normal controls were examined by using T1WI three-dimensional brain volume sequence ' to obtain the whole brain structural images. The images were analyzed by using VBM based on SPM5 to generate gray matter density map. Results Compared with normal controls, Parkinson's disease patients showed extensive decrease in gray matter density in widespread brain regions involving bilateral temporal, frontal, parietal, occipital lobes, right hippocampus, right parahip-pocampus gyrus, right cerebellar hemisphere and left caudate nucleus. Conclusion Gray matter atrophy in widespread brain region can exist in Parkinson's disease patients, which verifies that Parkinson's disease pathological damage can affect many different brain areas and can manifest variety symptoms. VBM can be used to evaluate the early structural changes of full-brain in vivo and is the first choice for the study of brain morphology.关键词
原发帕金森病/灰质/磁共振成像/基于体素的形态学分析Key words
parkinson's disease/ gray matter/ magnetic resonance imaging/ voxel-based morphometry分类
医药卫生引用本文复制引用
张静,张云亭,张本恕,杨俊峰..原发帕金森病全脑灰质结构基于体素的MRI形态学分析[J].兰州大学学报（医学版）,2011,37(3):71-75,5.
