军医进修学院学报2011，Vol.32Issue(8)：837-838,2.
拉米夫定应用史对恩替卡韦单用治疗耐阿德福韦的慢性乙型肝炎患者疗效的影响
Influence of using lamivudine on therapeutic efficacy of entecavir in chronic hepatitis B patients on adefovir therapy
赵攀 1杨昊臻 1祁京 2唐彦 1管群 1高月明 3齐冬颖1
作者信息
- 1. 解放军第302医院,肝衰竭诊疗研究中心,北京,100039
- 2. 解放军总后勤部第三门诊部,北京,100850
- 3. 解放军总医院,学员队,北京,100853
- 折叠
摘要
Abstract
Objective To evaluate the influence of using lamivudine on therapeutic efficacy of entecavir monotherapy in chronic hepatitis B patients on adefovir therapy. Methods Papers in Chinese and English(published before May, 2010) on the therapeutic efficacy of entecavir monotherapy in chronic hepatitis B patients on adefovir therapy were searched. A meta-analysis was performed for the papers that were divided into different groups according to the history of using lamivudine and the serum HBV DNA level, with the relative risk calculated as the therapeutic efficacy. Results Only 2 English papers were included. The average relative risk was 0.52 and the confidence interval was 0.29-0.93. Conclusion The history of using lamivudine reduces the therapeutic efficacy of entecavir monotherapy in chronic hepatitis B patients on adefovir therapy.关键词
肝炎,乙型/核苷类/Meta分析Key words
Hepatitis B/ Nucleosides/ Meta-Analysis分类
医药卫生引用本文复制引用
赵攀,杨昊臻,祁京,唐彦,管群,高月明,齐冬颖..拉米夫定应用史对恩替卡韦单用治疗耐阿德福韦的慢性乙型肝炎患者疗效的影响[J].军医进修学院学报,2011,32(8):837-838,2.
