口服补镁对老年2型糖尿病大鼠胰岛素敏感性的影响OACSTPCD
Effect of oral magnesium supplementation on insulin sensitivity in aged rats with type 2 diabetes
目的 研究口服补镁对老年2型糖尿病大鼠胰岛素敏感性的影响.方法 给2型糖尿病大鼠动物模型口服补镁,应用高胰岛素、正葡萄糖钳夹技术测定稳态下葡萄糖输注率、空腹血糖、空腹胰岛素及血浆镁离子浓度等指标.结果 中、高剂量口服补镁可降低空腹血糖达11.3％和21.9％,胰岛素水平下降分别达25.4％和38.7％,钳夹实验中稳态葡萄糖输注率也有明显提高.结论 口服补镁可显著改善老年2型糖尿病大鼠胰岛素敏感性.
Objective To investigate the effect of oral magnesium on insulin sensitivity in aged rats with type 2 diabetes. Methods An aged rat model of type 2 diabetes was induced by oral magnesium. Glucose infusion rate and levels of fasting glucose, insulin, and plasma magnesium ions in the rat model were measured using the euglycaemic-hyperinsulinaemic clamp technique. Results The medium and high doses of oral magnesium reduced the fasting blood glucose by 11.…查看全部>>
钟文雯;谷昭艳;方福生;闫双通;李春霖
解放军总医院,南楼内分泌科,北京,100853解放军总医院,南楼内分泌科,北京,100853解放军总医院,南楼内分泌科,北京,100853解放军总医院,南楼内分泌科,北京,100853解放军总医院,南楼内分泌科,北京,100853
临床医学
镁2型糖尿病胰岛素敏感性大鼠
Magnesium Diabetes Mellitus.Type 2 Insulin Sensitivity Rats
《军医进修学院学报》 2011 (8)
镁对老年2型糖尿病胰岛素受体活性的影响与机理研究
858-859,865,3
国家自然科学基金项目(30901187)
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