中国肺癌杂志2011，Vol.14Issue(7)：620-624,5.DOI:10.3779/j.issn.1009-3419.2011.07.11
上皮细胞间质化与肿瘤的转移
Epithelial-mesenchymal Transition and Tumor Metastasis
摘要
Abstract
Metastasis is the transfer of malignant tumors from one organ to a distant organ. It is the most common cause of death in cancer patients. Different molecular mechanisms enable tumor cells to infiltrate the surrounding tissue, invade blood vessels and leave the blood stream at a different site. Epithelial-mesenchymal transition (EMT) is critical for appropriate embryonic development, and this process is re-engaged in adults during wound healing, tissue regeneration, organ fibrosis, and cancer progression. EMT is the first step in tumor invasion and metastasis. A detailed knowledge of the molecular requirements for EMT in human cancer will help us to better understand tumor progression and to delineate more effective strategies for future therapeutic intervention.关键词
上皮细胞间质化；肿瘤侵润；转移Key words
Epithelial-mesenchymal transition/Tumor invasion/Metastasis分类
医药卫生引用本文复制引用
赵荣志..上皮细胞间质化与肿瘤的转移[J].中国肺癌杂志,2011,14(7):620-624,5.基金项目
本研究受国家自然科学基金重点项目(No.30430300)、国家自然科学基金项目(No.81000950)、国家“863”重大项目(No.2006 AAOZA401)和国家“973”重大项目(No.2010CB529405)基金资助 （No.30430300）
