中国药房2011，Vol.22Issue(36)：3382-3386,5.
扶正化瘀胶囊联合核苷类抗病毒药物治疗慢性乙型肝炎肝纤维化的系统评价
Fuzheng Huayu Capsules Combined with Nucleoside Antiviral Drug in the Treatment of Chronic Hepatitis B Liver Fibrosis: A Systematic Review
摘要
Abstract
OBJECTIVE: To evaluate the efficacy and safety of Fuzheng huayu capsule combined with nucleoside antiviral drugs for chronic hepatitis B liver fibrosis. METHODS: Retrieved from CBD, Wanfang database, CSJD, CNKI, PubMed, EM-Base and related journals, literatures meeting inclusion criteria were collected. Meta-analysis was performed by RevMan 5.0 software. RESULTS: 10 RCT were included, involving 792 cases of chronic hepatitis B. Results of Meta-analysis showed: after treatment of 24 and 48 weeks, hyaluronic acid in the experimental group were better than the control group, the differences were statistically significant [MD=-65.80,95%CI(-90.88,-40.73), MD=-82.40, 95%CI( - 140.99,-23.81)], and Laminin in the experimental group were better than the control group, the differences were statistically significant [MD=-29.08,95%CI (-36.57,-21.59), MD=-68.89,95%CI( -107.45, -30.33)]; After the treatment of 24 weeks, procollagen type I in the experimental group was better than the control group, the differences were statistically significant [MD= -27.70,95%CI (-47.86, -7.55)], the experimental group was still better than the control group at 48 weeks, but the difference was not statistically significant [MD= - 61.69,95%CI( -124.50,1.12)]; After the treatment of 24 and 48 weeks, collagen type IV (C IV ) in the experimental group were better than the control group, the differences were statistically significant [MD=-27.77,95%CI( -36.18, -19.36), MD= -57.58,95%CI( -104.42, -10.74)]. There were no statistically significant in both group of safty. CONCLUSION: The effect of Fuzheng huayu capsules combined with nucleoside antiviral drug is better than antiviral nucleoside antiviral drug alone in the treatment of chronic hepatitis B liver fibrosis. And adverse effect of liver and kidney hardly appear, but limited by the quality of included studies, the above conclusions still need high-quality clinical trials for further confirmation.关键词
扶正化瘀胶囊/核苷类抗病毒药物/慢性乙型肝炎/肝纤维化/系统评价Key words
Fuzheng huayu capsules/ Nucleoside antiviral drugs/ Chronic hepatitis B/ Liver fibrosis/ System evaluation分类
医药卫生引用本文复制引用
余燕青,周权,冯德云..扶正化瘀胶囊联合核苷类抗病毒药物治疗慢性乙型肝炎肝纤维化的系统评价[J].中国药房,2011,22(36):3382-3386,5.基金项目
国家自然科学基金资助项目(30671846) （30671846）
