中国药房2011，Vol.22Issue(36)：3394-3395,2.
卡介菌多糖核酸对慢性阻塞性肺疾病患者免疫功能的影响
Effect of BCG Polysaccharides Nucleic Acid on Immunologic Function in Patients with Chronic Obstructive Pulmonary Disease
摘要
Abstract
OBJECTIVE: To study the effect of PSN polysaccharides nucleic acid on immunologic function in patients with chronic obstructive pulmonary disease (COPD). METHODS: 60 COPD patients were randomly divided into 2 groups, COPD treatment group (n=30) and COPD control group (n=30). COPD treatment group received BCG-PSN polysaccharides nucleic acid (0.35 mg·mL-1 intramuscular injection, 3 times a week) and conventional therapy while COPD control group only received conventional therapy. The patients in 2 groups were followed up for 1 month. T lymphocyte subpopulation(CD3+,CD4+,CD8+, CD4+ CD8+), NK and B lymphocyte percentages were determined before and after treatment. RESULTS: After treatment, CD4+, CD4+/ CD8+ and B lymphocyte in COPD treatment group were significantly increased (P<0.05), while CD8+ were decreased (P<0.05). CD4+, CD47CD8+ and B lymphocyte in COPD treatment group were higher than COPD control group (P<0.05) while CD8+ were decreased (P<0.05). CONCLUSION: BCG-PSN can improve immunity in patients with COPD. It is of significance in the prevention and treatment of COPD.关键词
慢性阻塞性肺疾病/淋巴细胞/卡介菌多糖核酸/免疫功能Key words
Chronic obstructive nulmonarv disease: Lvmohocvte: BCG-PSN: Immunity分类
医药卫生引用本文复制引用
张湘燕,张程,王娜,徐琳,吴瑞明,杨杰,钱佳北..卡介菌多糖核酸对慢性阻塞性肺疾病患者免疫功能的影响[J].中国药房,2011,22(36):3394-3395,2.基金项目
贵州省发展和改革委员会资助项目(黔发改高技[2006]858号) （黔发改高技[2006]858号）
