中国药房2011，Vol.22Issue(36)：3411-3413,3.
氯吡格雷治疗急性冠脉综合征的临床疗效及其对血小板P选择素和C反应蛋白的影响
Clinical Efficacy of Clopidogrel in the Treatment of Acute Coronary Syndrome and Effect of It on Serum Platelet P-selection and C-reactive Protein
赵助飞 1王飞2
作者信息
- 1. 浙江诸暨市第二人民医院内科,诸暨市311811
- 2. 浙江诸暨市中医院急诊科,诸暨市311800
- 折叠
摘要
Abstract
OBJECTIVE: To observe the clinical efficacy of clopidogrel in the treatment of acute coronary syndrome (ACS), and to investigate the effects of it on serum platelet P-selection and C-reactive protein (CRP). METHODS: 100 ACS patients were randomly divided into treatment group and control group. Control group was given conventional therapy of aspirin, and treatment group was given clopidogrel combined with conventional therapy of aspirin. The clinical efficacy was observed after treatment for 6 months. Before treatment and after treatment the serum platelet P-selection and CRP levels were detected. RESULTS: The total effective rate of treatment group was 94.0%, and that of control group was 76.0%, there was significant difference (P<0.05). After treatment, the serum platelet P-selection and CRP levels of treatment group decreased significantly, compared with before treatment and control group the difference was significant (f<0.05); The serum platelet P-selection and CRP were positive correlation (r= 0.571, P=0.001). CONCLUSION: The serum platelet P-selection and CRP play an important role in the occurrence and disease progression of ACS. The clopidogrel therapy for CAS has obvious curative effect and can inhibit platelet activation and inflammatory response.关键词
氯吡格雷/血小板P选择素/C反应蛋白/急性冠脉综合征Key words
Clopidogrel/ Platelet P-selection/ C-reactive protein/ Acute coronary syndrome分类
医药卫生引用本文复制引用
赵助飞,王飞..氯吡格雷治疗急性冠脉综合征的临床疗效及其对血小板P选择素和C反应蛋白的影响[J].中国药房,2011,22(36):3411-3413,3.
