河北医学Issue(11)：1424-1436,13.DOI:10.3969/j.issn.1006-6233.2011.11.005
黄芩茎叶总黄酮对大鼠学习记忆的影响及抗氧化作用机制研究
The Effect of SSTF on Learning and Memory and its Anti-oxidative Mechanism in Rats
王秋杰 1辛立升 2吴晓光 3王瑞婷 3李越东4
作者信息
- 1. 河北省承德市医学情报站， 河北 承德067000
- 2. 承德医学院附属医院， 河北 承德 067000
- 3. 承德医学院， 河北 承德 067000
- 4. 河北省承德市妇幼保健院， 河北 承德067000
- 折叠
摘要
Abstract
Objective: To explore the effect of SSTF on learning and memory in rats and its anti-oxida-tive mechanism. Method; A(325-35 was administered in bilateral hippocampus of wistar male rats to make AD model. Morris Water Maze was used to observe the rats learning and memory. The activity of SOD and content of MDA in serum were detected. Result: In SSTF group , the latency finding the hidden platform on 6th day significantly decreased, the activity of SOD significantly increased, content of MDA significantly decreased compared with those of model group. Conclusion: SSTF could attenuate the learning and memory dysfunction, the mechanism might be related to its anti-oxidative effect.关键词
黄芩茎叶总黄酮/淀粉样蛋白/超氧化物岐化酶/丙二醛Key words
Scutellaria Baicalensis Stem-leaf Total Flavonoid / Amyloid protein/ Superoxide dis-mutase (SOD) / Malondialdehyde ( MDA)引用本文复制引用
王秋杰,辛立升,吴晓光,王瑞婷,李越东..黄芩茎叶总黄酮对大鼠学习记忆的影响及抗氧化作用机制研究[J].河北医学,2011,(11):1424-1436,13.
