中国兽医科学2011，Vol.41Issue(6)：636-640,5.
氟苯尼考琥珀酸钠的制备及其在家兔体内的药代动力学特征
Preparation of florfenicol sodium succinate and its pharmacokinetics characteristics in rabbits
摘要
Abstract
Florfenicol sodium succinate(Fl-Sna) was prepared using 4-dimethylaminopyridine(DMAP) as catalyst. The blood samples from the rabbits intramuscularly-injected with a single dose of either florfenicol solution or Fl-Sna solution were collected to measure florfenicol concentrations in plasma by high performance liquid chromatography (HPLC). The pharmacokinetic parameters were analyzed with DAS2. 0 software. In results,Fl-Sna was successfully prepared. The major pharmacokinetic parameters of florfenicol and Fl-Sna were shown as Cmax of 8. 863 mg/L±0. 254 mg/L vs. 7. 363 mg/L±0. 085 mg/L,tmax of 1. 0 h vs. 2. 0 h,and AUC of 28. 851 mg/L ? h±0. 494 mg/L ? h vs. 39. 187 mg/L ? h±0. 413 mg/L ? h,respectively. In conclusion,HPLC was suitable for the determination of florfenicol concentration in plasma of rabbits, and the Fl-Sna could significantly increase bioavailability of florfenicol in rabbits.关键词
氟苯尼考/氟苯尼考琥珀酸钠/家兔/药代动力学/高效液相色谱法Key words
florfenicol/Fl-Sna/rabbit/pharmacokinetics/HPLC分类
农业科技引用本文复制引用
符华林,张伟,陈静,唐文,周凤,付强,邓凤英,胡俊..氟苯尼考琥珀酸钠的制备及其在家兔体内的药代动力学特征[J].中国兽医科学,2011,41(6):636-640,5.基金项目
教育部"长江学者和创新团队发展计划"创新团队项目(IRT0848) （IRT0848）
