中国药房2011，Vol.22Issue(26)：2451-2453,3.
万古霉素在我院肝移植患者中的治疗药物监测及临床应用分析
Therapeutic Drug Monitoring and Clinical Utilization of Vancomycin in Liver Transplantation Recipients in Our Hospital
张弋 1吴瑛 2沈中阳1
作者信息
- 1. 天津市第一中心医院,天津市300192
- 2. 天津医科大学临床医学院,天津市300385
- 折叠
摘要
Abstract
OBJECTIVE: To evaluate the drag therapy of vancomycin in liver transplantation recipients, the change of kidney function and influencing factors of blood concentration. METHODS: The blood concentration monitoring data, bacterial culture, drag sensitivity test, kidney function change before and after administration in 64 liver transplantation recipients in organ transplantation center of our hospital from Jan. 2003 to Apr. 2009 were analyzed retrospectively. RESULTS: 396 times of blood concentration monitoring results of 64 liver transplantation recipients showed that average trough concentration of vancomycin was (16.41 ± 9.20) mg·L-1. The concentrations of 16.92% cases were 5~10 mg·L-1, that of 73.48% were more than 10 mg·L-1 and 9.60% were lower than 5 mg-L"1. The renal function showed significant differences before and after administration at trough concentration more than 10 mg·L-1(P<0.05). Through regression analysis, the main influencing factors of blood concentration were dose/body weight,Cr,age, ALT in order (P<0.05). CONCLUSION: Clinical achievable concentration of vancomycin is high relatively in liver transplantation recipients. Kidney function change should be monitored closely with blood concentration of vancomycin increasing. Clinical efficacy and DUI show that clinical application of vancomycin in our hospital is almost reasonable.关键词
万古霉素/肝移植/血药浓度监测/临床应用Key words
Vancomycin/ Liver transplantation/ Blood concentration monitoring/ Clinical application分类
医药卫生引用本文复制引用
张弋,吴瑛,沈中阳..万古霉素在我院肝移植患者中的治疗药物监测及临床应用分析[J].中国药房,2011,22(26):2451-2453,3.
