中山大学学报（医学科学版）Issue(5)：674-678,5.
非小细胞肺癌18F-FDG摄取与EGFR突变的关系
Relationship between 18F-FDG Uptake and EGFR Mutations in Non-Small Cell Lung Cancer
张亚锐 1张旭 1胡莹莹 1林晓平 1梁培炎 1樊卫1
作者信息
- 1. (中山大学肿瘤防治中心核医学科,广东广州510060)
- 折叠
摘要
Abstract
[Objective] The relationship between 18F-fluoro-2-deoxy-glucose (18F-FDG) uptake of primary tumor and epidermal growth factor receptor (EGFR) mutations in patients with non-small cell lung cancer (NSCLC) was investigated in this study. EGFR mutations were predicted by maximum standard uptake value (SUVmax) for clinical application of tyrosine kinase inhibitors (TKI). [Methods] Totally 66 patients dated from November 2006 to September 2010 were collected, who underwent PET / CT examinations and EGFR mutation tests by fluorescent quantitative PCR before any anti-tumor therapies. The 18F-FDG uptake of primary lesions was described with SUVmax, then the relationship was analyzed. [Results] EGFR mutations within exons 19 and 21 were detected in 22 NSCLC patients (33%). The SUVmax was significantly lower in EGFR mutant-type than wild-type ( 10 ± 5, 14 ± 6, P = 0.006). The SUVmax and EGFR mutations were performed as negative correlation (r = -0.344, P = 0.005). For the prediction of EGFR mutations by SUVmax, the area under the receiver operating characteristic curve (AUC) was 0.71 (P = 0.006), when the cut off value was 8.8, the Youden Index reached the maximum value (0.43). Patients with low SUVmax were more likely to carry EGFR mutations than those with high SUVmax (71%, 20%, P= 0.000). [Conclusion] The 18F-FDG uptake of primary rumor in NSCLC patients was negatively correlated with EGFR mutations, patients with lower SUVmax were more likely to harbor EGFR mutations. For the advanced NSCLC patient, it might be helpful to identify who is suitable to TKI treatment.关键词
EGFR突变/SUVmax/187F-FDG PET/CT/非小细胞肺癌Key words
epidermal growth factor receptor mutation/ SUVmax/ 18F-FDG PET/CT/ non-small cell lung cancer分类
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张亚锐,张旭,胡莹莹,林晓平,梁培炎,樊卫..非小细胞肺癌18F-FDG摄取与EGFR突变的关系[J].中山大学学报（医学科学版）,2011,(5):674-678,5.
