中国临床医学2011，Vol.18Issue(4)：453-455,3.
血红蛋白清道夫受体与冠状动脉斑块形态关系的临床研究
Relationship between Haemoglobin Scavenger Recaptor CD163 Expression and the Morphology of Atherosclerotic Plaque in Coronary Artery
付鑫 1吴桂平 1张彦红 1邓会明 1晏宁1
作者信息
- 1. 沈阳医学院沈洲医院心内科,辽宁沈阳 110002
- 折叠
摘要
Abstract
Objective: To investigate the relationship between haemoglobin scavenger recaptor CD163 expression and the morphology of atherosclerotic plaque in coronary artery. Methods: A total of 76 patients with coronary heart disease (CHD) were divided into the a-cute myocardial infarction(AMI) group(n = 20), the unstable angina pectoris(UAP) group(n= 26) and the stable angina pectoris (SAP) group(n = 30). By coronary angiography(CAG), 20 normal subjects without CHD diagnosed by CAG served as the control group. Expression levels of CD163 on monocytes were detected by means of flow cytometry.and the results were showns as mean fluorescence intensity(mfi). The relationships between CD163 and the morphology of atherosclerotic plaque in coronary artery were analyzed. Serum hs-CRP were also measured. Results: In AMI, UAP, SAP and the control group, the mean level of CD163 was (91. 18 ± 7. 29) mfi, (67.18 + 6.12) mfi, (39. 26 ± 5.37) mfi and (22. 78 ± 4.67) mfi.the mean level of CD163 was obviously higher in the AMI and UAP group than in the SAP and control group (P<0. 01). The level of CD163 was positive correlated with hs-CRP. Type II plaque was obviously higher in the AMI and UAP group than in the SAP group (P<0.01). Type H plaque may prone to rupture. The level of CD163 in typell was obviously higher than in the landffiplaque group. Conclusions: Aggravates along with coronary disease condition, the hemoglobin scavenger recaptor CD163's expression level elevates gradually, may reflect in vivo atherosclerosis related inflammation degree, in typell plaque group patient hemoglobin scavenger recaptor GDI63's expression obvious markup, may probably act as one of the biomarkers of vulnerable plaques.关键词
血红蛋白清道夫受体/C反应蛋白/冠状动脉Key words
Haemoglobin scavenger recaptor/C - reactive protein/Coronary artery分类
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付鑫,吴桂平,张彦红,邓会明,晏宁..血红蛋白清道夫受体与冠状动脉斑块形态关系的临床研究[J].中国临床医学,2011,18(4):453-455,3.
