山东医药2011，Vol.51Issue(34)：25-26,2.
高糖环境对豚鼠膀胱Cajal样间质细胞内向电流的影响
Impact of high concentrations of glucose environment on Ih in ICCs from bladder of adult guinea pigs
摘要
Abstract
Objective To observe the effect of high concentrations of glucose on Ih in ICCs from bladder of adult guinea pigs. Methods Primarily cultured bladder ICCs from adult guinea pigs were harvested by collagenase digestion. The whole-cell patch clamp technique was used to record the Ih in ICCs cultured in glucose concentration of 5 ( control group)、15 ( high glucose group I )、30 mmol/L ( high glucose group Ⅱ ) of culture medium. Result The Ih value in the control group was (505.75 ±157.660) pA, (349. 25 ±71.087) pA in high glucose group Ⅰ , (95.00 ±33. 337) pA in high glucose group Ⅱ, all P <0.05. Conclusion High concentrations of glucose environment can lead to lower current value of Ih, it may be one of the reasons causing the diabetic cystopathy.关键词
膀胱间质细胞/起搏电流/高糖环境/膀胱/糖尿病膀胱病变/豚鼠Key words
interstitial cells of Cajal-like/ Ih current/high glucose environment/bladder/diabetic cystopathy/guinea Pigs分类
医药卫生引用本文复制引用
徐礼臻,王勤章,韩涛,丁国富,马克涛,王江平..高糖环境对豚鼠膀胱Cajal样间质细胞内向电流的影响[J].山东医药,2011,51(34):25-26,2.基金项目
国家自然科学基金资助项目(30860281). （30860281）
