山东医药2011，Vol.51Issue(37)：1-3,3.
不同分期糖尿病肾病患者血清IL-18、CRP水平的变化及意义
Changes and significances of serum IL-18, CRP level in diabetic nephropathies patients in different stages
摘要
Abstract
Objective To study the serum IL-18, C-reaclive protein (CRP) level changes and their significances in diabetic nephropathies patients in different stages. Methods Ninety-seven cases of type 2 diabetes were chosed, and they were divided into three groups, namely normal albuminuria group (n =35) , microalbuminuria group (n =30) and protein-uria group(n =32) , according to urinary albumin excretion rate (UAER). Thirty-five healthy individuals were selected as the control group. The levels of serum IL-18 and CRP were detected by ELJSA, and their influential factors were analyzed. Results Compared with control group, IL-18, CRP levels in diabetic patients were significantly higher (P<0.05), and IL-18 levels gradually increased with the increasing of UAER ( P <0.01). Pearson correlation analysis showed that serum CRP, IL-18 were positively associated with disease, systolic blood pressure, glycated hemoglobin, fasting glucose, TG, TC, LDL-C, blood urea nitrogen, serum creatinine, UAER(rIL-18=0. 766, 0. 628, 0. 568, 0. 388, 0. 375, 0. 400, 0.512, 0.516,0.698, 0.792; rCRP =0.777, 0.701, 0.416, 0.327, 0.308, 0.307,0.449,0.611,0.817,0.893, P < 0.01), and negatively correlated with HDL-C(rIL-18 = -0.652,rCRP= -0.546, P<0.01). There was a positive correlation between IL-18 and CRP(r= 0.890, P<0.01). Conclusions IL-18 and CRP may be involved in the development of type 2 diabetic nephropathies, combined detection of both have important role in early diagnosis.关键词
糖尿病肾病/白细胞介素18/C反应蛋白质Key words
diabetic nephropathies/ interleukin-18/ C-reaction protein分类
医药卫生引用本文复制引用
唐灵,梁志清,刘树娇,苏桂兰,甄瑞峰..不同分期糖尿病肾病患者血清IL-18、CRP水平的变化及意义[J].山东医药,2011,51(37):1-3,3.基金项目
广西科学基金项目(桂科自0991263). （桂科自0991263）
